PRA crd3

 

Progressive retinal atrophy (PRA) is a heritable condition that causes gradual loss of sight in dogs; and cone-rod dystrophy 3 (crd3) is the Glen variant of PRA. In 2010, two research laboratories identified the gene mutation that causes crd3 ... and developed a DNA test. It is now possible for breeders to avoid producing puppies that are at risk of developing crd3 ... by ensuring that the crd3 status of both the sire and dam is known, and that at least one parent is either known to be hereditary clear (HC) or has been DNA tested clear for crd3. 

​Both UK breed clubs provide "best practice" guidance to breeders in their Codes of Ethics:

  • "The crd3 status of both parents should be known, or established by DNA test prior to (first) mating" (EFG)

  • "At least one parent to be either Hereditary Clear or DNA tested Clear, to ensure that the puppies are not at risk of developing the blinding disorder, GPRA-crd3" (EFG)

  • "All parents must be DNA tested unless hereditary clear of gPRA/crd3" (GOITA)

Breeders: For more information about testing for PRA crd3, please see the box below.

 

Puppy buyersAsk the breeder about PRA crd3

 

DNA test for PRA crd3

The DNA test involves sending a blood sample or buccal (mouth) swabs from your Glen, to one of the Kennel Club's recognised laboratories.

This is a "one-off" test to determine the crd3 status of your Glen -- clear or carrier or affected.

How do I get my Glen DNA tested for PRA crd3?

The Kennel Club lists three laboratories that offer DNA testing for crd3:

Biofocus (Recklinghausen, Gemany)

The EFG breed club has an arrangement with Biofocus for this test.

  • Please contact Mrs Jean Rogers, EFG secretary for further details: jean@e-f-g.co.uk

  • Biofocus do NOT notify the Kennel Club of the result, so please forward, or scan & email the result certificate to: 

       health.results@thekennelclub.org.uk 

 

Pet Genetics Lab (Isle of Man, UK)

  • Sample: Swab

  • Cost: £40.00

  • Name of test: Progressive Retinal Atrophy (PRA-crd3)

  • Please click here to order the DNA test for your Glen 

  • PGL will notify the Kennel Club of the result, which will be published on the KC's Health Test Results Finder

Van Haeringen Lab (Wageningen, Netherlands)

  • Sample: Swab or blood EDTA

  • Cost: €111.17

  • Name of test: crd3 (CODE H856)

  • Please click here to order the DNA test for your Glen

  • This test is performed by VHL's partner lab, Wisdom Health 

  • VHL do NOT notify the Kennel Club of the result, so please forward, or scan & email the result certificate to: 

       health.results@thekennelclub.org.uk 

Results

You will be informed of the result by the lab to whom you have sent the sample, and a certificate should be available within two or three weeks. Results are published in the Kennel Club's quarterly Breed Records Supplement, and on the Health Test Results Finder.

N.B. Please check that your Glen's result is published on the Health Test Results Finder ... and that the result is correct!

 

For any queries or corrections, please contact the Kennel Club's Health & Breeder Services department: 

health.results@thekennelclub.org.uk.

Contact: glenofimaalhealth@gmail.com

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